Regulation of Ferroptotic Cancer Cell Death by GPX4
Abstract
Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown. We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules. We used targeted metabolomic profiling to discover that depletion of glutathione causes inactivation of glutathione peroxidases (GPXs) in response to one class of compounds and a chemoproteomics strategy to discover that GPX4 is directly inhibited by a second class of...
Paper Details
Title
Regulation of Ferroptotic Cancer Cell Death by GPX4
Published Date
Jan 1, 2014
Journal
Volume
156
Issue
1-2
Pages
317 - 331
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Notes
History