A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
Abstract
This report describes the design, generation and testing of Ylanthia, a fully synthetic human Fab antibody library with 1.3E+11 clones. Ylanthia comprises 36 fixed immunoglobulin (Ig) variable heavy (VH)/variable light (VL) chain pairs, which cover a broad range of canonical complementarity-determining region (CDR) structures. The variable Ig heavy and Ig light (VH/VL) chain pairs were selected for biophysical characteristics favorable to...
Paper Details
Title
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
Published Date
May 1, 2013
Journal
Volume
5
Issue
3
Pages
445 - 470
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