Tolerance to the protective effect of salmeterol in mild untreated asthmatics

The aim of this study was to assess the distribution of the occurrence of tolerance to the protective effect of salmeterol on allergen challenge in a large sample of asthmatic subjects. We investigated 53 subjects (45 male and eight female), mean age 24±8.2 years, with mild intermittent asthma, in stable phase of the disease, never previously treated with regular β2-agonists. All subjects with a previous positive early airway response (EAR) to a...