Industrial Utilization of Tin-Initiated Resorbable Polymers: Synthesis on a Large Scale with a Low Amount of Initiator Residue

This article presents the successful large-batch synthesis of a resorbable polymer with a minimal amount of residual tin. Ring-opening polymerization of epsilon-caprolactone was performed in toluene, with a tin (IV) alkoxide as the initiator. A number of parameters were varied in order to study the polymerization with respect to the purity of solvent, batch size, and the residual amount of tin in the polymers. The synthesis of...