Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer
Abstract
The current understanding of the molecular mechanisms that lead to cancer is not sufficient to explain the loss or gain of function in proteins related to tumorigenic processes. Among them, more than 100 oncogenes, 20-30 tumor-suppressor genes, and hundreds of genes participating in DNA repair and replication have been found to play a role in the origins of cancer over the last 25 years. The phosphorylation of serine, threonine, or tyrosine...
Paper Details
Title
Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer
Published Date
Apr 29, 2015
Journal
Volume
5
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