Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Abstract
Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a...
Paper Details
Title
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Published Date
Apr 1, 2013
Journal
Volume
14
Issue
4
Pages
372 - 379
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Notes
History