Recurrent Micronucleation through Cell Cycle Progression in the Presence of Microtubule Inhibitors
Abstract
Although most cell lines undergo mitotic arrest after prolonged exposure to microtubule inhibitors, some cells subsequently exit this state and become tetraploid. Among these cells, limited numbers of rodent cells are known to undergo multinucleation to generate multiple small independent nuclei, or micronuclei by prolonged colcemid treatment. Micronuclei are thought to be formed when cells shift to a pseudo G1 phase, during which the onset of...
Paper Details
Title
Recurrent Micronucleation through Cell Cycle Progression in the Presence of Microtubule Inhibitors
Published Date
Jan 1, 2015
Journal
Volume
40
Issue
1
Pages
51 - 59
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