Rosette forming glioneuronal tumor in association with Noonan syndrome: pathobiological implications

Noonan syndrome, a distinc- tive syndrome characterized by dysmor- phism, cardiac abnormalities and develop- mental delay, has been associated with a number of malignancies, however, only a few cases of primary glial or glioneuronal neoplasms have been reported. We report here the case of an 18-year-old with Noonan syndrome who developed a rosette forming glioneuronal tumor of the posterior fossa. The tumor demonstrated strong pERK im-...