RI-Dom, a Cell-Penetrating Peptide. Interaction with DNA and Membranes
Abstract
riDOM (retro-inverso-dioleoyl-melittin) is a cell penetrating peptide with excellent transporter properties for DNA. It is a chimeric molecule where ri-melittin is fused to dioleoylphosphoethanolamine. The physical-chemical properties of riDOM in solution and in the presence of DNA, heparan sulfate and lipid membranes were investigated with spectroscopic and thermodynamic methods. riDOM in solution forms nanoparticles with a diameter of ∼13 nm,...
Paper Details
Title
RI-Dom, a Cell-Penetrating Peptide. Interaction with DNA and Membranes
Published Date
Jan 28, 2014
Journal
Volume
106
Issue
2
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History