Caveolin-3 Directly Interacts and Regulates the Function of Cardiac CaV3.2 (A1H) T-Type Ca2+ Channels

Voltage-gated T-type Ca2+ channel (TTCC), Cav3.1 and Cav3.2, are normally expressed during cardiac development but are re-expressed in cardiac hypertrophy and may contribute to the altered intracellular Ca2+ during this disease. However, the mechanism of altered Ca2+ signaling in cardiac hypertrophy is not clearly known. Caveolae containing scaffolding protein caveolin-3 (Cav-3), provide spatiotemporal regulation of intracellular Ca2+ in...