Knockout of a putative ergothioneine transporter inCaenorhabditis elegansdecreases lifespan and increases susceptibility to oxidative damage
Abstract
In addition to excretion of metabolic waste products, organic ionic transporters facilitate uptake of specific compounds of physiological importance. In animals, the organic cation transporter, OCTN1 was found to enable the specific uptake of the unique amino acid, ergothioneine (EGT). EGT can accumulate in the body at up to millimolar concentrations and is believed to function as a physiological antioxidant. However the main function of EGT and...
Paper Details
Title
Knockout of a putative ergothioneine transporter inCaenorhabditis elegansdecreases lifespan and increases susceptibility to oxidative damage
Published Date
Oct 24, 2013
Journal
Volume
47
Issue
12
Pages
1036 - 1045
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