Protection by extracellular glutathione against sulfur mustard induced toxicity in vitro

1 The present study characterizes the role of extracellularly added glutathione in protection against sulfur mustard (HD) toxicity in a macrophage monocyte cell line J774. 2 Toxic effects of HD depend on dose and duration of exposure with an ED 50 of 50 and 75 mM for dividing and confluent cells respectively. 3 Exposure to HD, 100-200 mM caused *15% decrease in the cellular glutathione (GSH) content 2 h after exposure, pretreatment with GSH,...