Composites of Calcium Phosphate and Polymers as Bone Substitution Materials

Published on Apr 1, 2006in European Journal of Trauma and Emergency Surgery2.139
· DOI :10.1007/S00068-006-6044-Y
Markus Neumann5
Estimated H-index: 5
,
Matthias Epple77
Estimated H-index: 77
(University of Duisburg-Essen)
Source
Abstract
The state of the art of calcium phosphate/polymer composites for bone substitution is reviewed. Many combinations are possible which were proposed to improve the mechanical properties and the biocompatibility. However, the way from the laboratory to the clinical application is long, and potential candidates for new bone substitution materials have to meet many different requirements.
📖 Papers frequently viewed together
3,585 Citations
1,008 Citations
200010.32Biomaterials
1 Author (Karine Anselme)
2,769 Citations
References52
Newest
#1W. Linhart (UHH: University of Hamburg)H-Index: 18
#1Wolfgang Linhart (UHH: University of Hamburg)H-Index: 13
Last. Matthias Epple (University of Duisburg-Essen)H-Index: 77
view all 9 authors...
Composites of amorphous carbonated apatite and poly-(R)-3-hydroxybutyrate (PHB) and poly-(R)-3-hydroxybutyrate-co-(R)-3-hydroxyvalerate (PHBHV), respectively, were studied by pH monitoring upon immersion in water and by long-term osteoblast culture. For comparison, α-tricalcium phosphate (α-TCP), one glass ceramic (GB 9N), and one bioglass (Mg 5) were subjected to the same experiments. Excellent cell proliferation was found on the composite of calcium phosphate with PHB and on the reference mate...
21 CitationsSource
#1Filippo Causa (University of Naples Federico II)H-Index: 26
#2Paolo A. Netti (University of Naples Federico II)H-Index: 68
Last. Armando Giunti (UNIBO: University of Bologna)H-Index: 37
view all 8 authors...
Polycaprolactone (PCL), a semicrystalline linear resorbable aliphatic polyester, is a good candidate as a scaffold for bone tissue engineering, due to its biocompatibility and biodegradability. However, the poor mechanical properties of PCL impair its use as scaffold for hard tissue regeneration, unless mechanical reinforcement is provided. To enhance mechanical properties and promote osteoconductivity, hydroxyapatite (HA) particles were added to the PCL matrix: three PCL-based composites with d...
259 CitationsSource
#1Shin Hasegawa (Kyoto University)H-Index: 5
#2Jiro Tamura (Kyoto University)H-Index: 24
Last. Takashi Nakamura (Kyoto University)H-Index: 62
view all 8 authors...
We investigated the biocompatibility, osteoconductivity, and biodegradability of a porous composite of hydroxyapatite (HA) and poly-DL-lactide (PDLLA) implanted into rabbit femoral condyles and compared it with porous HA. Six weeks after implantation, the HA/PDLLA was covered with bone and contacted the bone directly. The amount of newly formed bone in the pores was similar in both materials during the examined period. The newly formed bone in the HA/PDLLA tended to increase over 26 weeks, but t...
94 CitationsSource
#1Atsuro Yokoyama (Hokkaido University)H-Index: 27
#1Atsuro Yokoyama (Hokkaido University)H-Index: 7
Last. Fumio Watari (Hokkaido University)H-Index: 60
view all 7 authors...
Histological investigations of a new hydroxyapatite–collagen composite material were carried out to evaluate its possible suitability as a bone substitute. The three-dimensional scaffolds made from biomimetically mineralized collagen exhibit an interconnecting pore structure and elastic mechanical properties. They were implanted into the subcutaneous tissue and bone defects made in the femur of rats and harvested with the surrounding tissue at 1, 2, 4, 8, and 12 weeks after surgery. The material...
105 CitationsSource
#1Lijun Kong (THU: Tsinghua University)H-Index: 11
#2Yuan Gao (THU: Tsinghua University)H-Index: 8
Last. Xiufang Zhang (THU: Tsinghua University)H-Index: 33
view all 6 authors...
A novel nano-hydroxyapatite (HA)/chitosan composite scaffold with high porosity was developed. The nano-HA particles were made in situ through a chemical method and dispersed well on the porous scaffold. They bound to the chitosan scaffolds very well. This method prevents the migration of nano-HA particles into surrounding tissues to a certain extent. The morphologies, components, and biocompatibility of the composite scaffolds were investigated. Scanning electron microscopy, porosity measuremen...
312 CitationsSource
#1P. Quinten Ruhé (Radboud University Nijmegen)H-Index: 7
#2Elizabeth L. Hedberg (Rice University)H-Index: 9
Last. Antonios G. Mikos (Rice University)H-Index: 153
view all 6 authors...
Injectable calcium phosphate (Ca-P) cement materials exhibit favorable osteocompatible behavior but are resorbed slowly because of a lack of a bone ingrowth-enabling macroporosity. In this study, poly(DL-lactic-co-glycolic acid) (PLGA) microparticles (average size 66 +/- 25 microm) were incorporated into Ca-P cement to obtain a macroporous Ca-P cement scaffold after PLGA hydrolysis in vivo. Preset PLGA/Ca-P cement composite discs of various weight ratios (0/100, 15/85, 30/70, and 50/50) were imp...
184 CitationsSource
#1John D. Bartlett (The Forsyth Institute)H-Index: 52
#2S.E. DwyerH-Index: 1
Last. Tracie L. Payne-Ferreira (Harvard University)H-Index: 6
view all 5 authors...
Fluoride is an effective agent for the prevention of dental caries. However, the mechanism of how excessive fluoride exposure causes fluorosis remains uncertain. Zebrafish (Danio rerio) exhibit periodic tooth replacement throughout their lives, thereby providing continuous access to teeth at developmental stages susceptible to fluoride exposure. Zebrafish teeth do not contain true enamel, but consist of a hard enameloid surface. Therefore, we asked whether zebrafish could be used as a model orga...
57 CitationsSource
#1Chao Zou (ZJU: Zhejiang University)H-Index: 4
#1Chao Zou (ZJU: Zhejiang University)H-Index: 23
Last. Gaorong Han (ZJU: Zhejiang University)H-Index: 56
view all 8 authors...
Abstract Porous β -tricalcium phosphate (TCP)/collagen composites with different β -TCP/collagen weight ratio were prepared. The influences of the preparation conditions on the microstructure of porous composite and the joint status of β -TCP particles with collagen fibrils were characterized by X-ray diffractometer, scanning electron microscopy and transmission electron microscopy. The results showed: (1) an acid treatment could effectively disassemble collagen fibrils; (2) in the resulting por...
99 CitationsSource
#1Yoshitake Takahashi (Kyoto University)H-Index: 9
#2Masaya Yamamoto (Kyoto University)H-Index: 43
Last. Yasuhiko Tabata (Kyoto University)H-Index: 123
view all 3 authors...
Abstract Biodegradable gelatin sponges at different contents of β -tricalcium phosphate ( β -TCP) were fabricated to allow bone morphogenetic protein (BMP)-2 to incorporate into them. The in vivo osteoinduction activity of the sponges incorporating BMP-2 was investigated, while their in vivo profile of BMP-2 release was evaluated. The sponges prepared had an interconnected pore structure with an average pore size of 200 μm, irrespective of the β -TCP content. The in vivo release test revealed th...
348 CitationsSource
#1Hae-Won Kim (SNU: Seoul National University)H-Index: 85
#2Jonathan C. Knowles (UCL: University College London)H-Index: 91
Last. Hyoun-Ee Kim (SNU: Seoul National University)H-Index: 81
view all 3 authors...
Gelatin-hydroxyapatite (HA) nanocomposite porous scaffolds were fabricated biomimetically, and their feasibility as a drug-delivery carrier for tissue-regeneration and wound-healing treatments was addressed. The composite sols were prepared by the precipitation of HA up to 30 wt % within a gelatin solution with the use of calcium and phosphate precursors, and the porous scaffold was obtained by casting the sols and further freeze drying. The obtained bodies were crosslinked with carbodiimide der...
164 CitationsSource
Cited By84
Newest
#1Lena Schröter (University of Ulm)H-Index: 1
#2Friederike Kaiser (University of Würzburg)H-Index: 1
Last. Anita Ignatius (University of Ulm)H-Index: 65
view all 5 authors...
Abstract Calcium phosphate cements (CPCs) have been used to treat bone defects and support bone regeneration because of their good biocompatibility and osteointegrative behavior. Since their introduction in the 1980s, remarkable clinical success has been achieved with these biomaterials, because they offer the unique feature of being moldable and even injectable into implant sites, where they harden through a low-temperature setting reaction. However, despite decades of research efforts, two maj...
4 CitationsSource
#1Roman V. ChernozemH-Index: 10
#2Olga Guselnikova (Tomsk Polytechnic University)H-Index: 15
Last. Roman A. SurmenevH-Index: 26
view all 10 authors...
Abstract Biodegradable piezoelectric 3D polymer scaffolds attract great attention due to possibilities to mimic the functional and mechanical properties of the extracellular matrix, avoiding secondary surgery, and electrically stimulated tissue repair. However, the preservation of piezoelectric response and improvement of wettability of hydrophobic fibrous polymer scaffolds, limiting their application in tissue engineering and regenerative medicine, is a challenge. Here, a facile and mild approa...
3 CitationsSource
#1Iris FlaigH-Index: 1
#2Milena Radenković (University of Niš)H-Index: 1
Last. Mike BarbeckH-Index: 31
view all 6 authors...
Jellyfish collagen, which can be defined as “collagen type 0” due to its homogeneity to the mammalian types I, II, III, V, and IX and its batch-to-batch consistent producibility, is of special interest for different medical applications related to (bone) tissue regeneration as an alternative to mammalian collagen-based biomaterials. However, no in vivo studies regarding the induction of M1- and M2-macrophages and their time-dependent ration as well as the analysis of the bone regeneration capaci...
7 CitationsSource
#2Barbara Romelczyk-Baishya (Warsaw University of Technology)H-Index: 3
Last. Witold LojkowskiH-Index: 29
view all 8 authors...
Composites made of a biodegradable polymer, e.g., polylactic acid (PLA) and hydroxyapatite nanoparticles (HAP NPs) are promising orthopedic materials. There is a particular need for biodegradable hybrid nanocomposites with strong mechanical properties. However, obtaining such composites is challenging, since nanoparticles tend to agglomerate, and it is difficult to achieve good bonding between the hydrophilic ceramic and the hydrophobic polymer. This paper describes a two-step technology for obt...
2 CitationsSource
#1Matthew N. George (Mayo Clinic)H-Index: 6
#2Xifeng Liu (Mayo Clinic)H-Index: 15
Last. Lichun Lu (Mayo Clinic)H-Index: 49
view all 5 authors...
A current approach in bone tissue engineering is the implantation of polymeric scaffolds that promote osteoblast attachment and growth as well as biomineralization. One promising polymer is oligo[poly(ethylene glycol) fumarate] (OPF), a polyethylene glycol-based material that is biocompatible, injectable, and biodegradable, but in its native form does not support robust bone cell attachment or growth. To address this issue, this study evaluated the osteoconductivity of bis[02-(methacryloyloxy)et...
5 CitationsSource
#1E. S. Trofimchuk (MSU: Moscow State University)H-Index: 7
#2M. A. Moskvina (MSU: Moscow State University)H-Index: 8
Last. Sergey N. Chvalun (RAS: Russian Academy of Sciences)H-Index: 14
view all 9 authors...
Experimental conditions have been established for the preparation of stable open-pore matrices with pore diameters of 10–20 nm on the basis of semicrystalline polylactide films by thedelocalized crazing mechanism. The synthesis of phosphates of calcium (brushite) and magnesium (struvite) in the pores of such a polymer matrix allows one to tune the size of the formed crystallites, which has appeared to be about 30 nm, and to obtain nanocomposites with high dispersity of the components. The result...
3 CitationsSource
Orthopedic surgical procedures based on the use of conventional biological graft tissues are often associated with serious post-operative complications such as immune rejection, bacterial infection, and poor osseointegration. Bioresorbable bone graft substitutes have emerged as attractive alternatives to conventional strategies because they can mimic the composition and mechanical properties of the native bone. Among these, bioactive glasses (BGs) hold great potential to be used as biomaterials ...
16 CitationsSource
The aim of this study was to investigate the mechanical properties of polymeric composites prepared via extrusion and injection moulding. Four stable thermoplastic polymers were used as composites matrices (two kinds of polymethyl methacrylate and two kinds of co-polymer acrylonitrile-butadiene-styrene). Silver nanoparticles AgNPs were used as a modifying phase. Mechanical properties of testes materials were determined during the uniaxial stretching. Surface properties such as roughness and cont...
3 CitationsSource
#1Kanupriya Khurana (UPC: Polytechnic University of Catalonia)H-Index: 3
#2Frank Müller (Saarland University)H-Index: 24
Last. Maria-Pau Ginebra (UPC: Polytechnic University of Catalonia)H-Index: 58
view all 9 authors...
Abstract One of the treatments for recurrent or complicated osteomyelitis is by local antibiotherapy mediated by suitable bone grafts. β–Tricalcium Phosphate (β–TCP) bioceramic is a resorbable bone graft. Its microporosity allows for incorporation of drugs, but a too fast release is often obtained. Complex strategies have been explored to obtain controlled drug release. In this work, plasma polymerization of a biocompatible polymer was investigated on β-TCP. Polyethyleneglycol (PEG)-like polymer...
1 CitationsSource
#1Lubomir MedveckyH-Index: 9
#2R. StulajterovaH-Index: 5
Last. Mária FáberováH-Index: 15
view all 4 authors...
Source