Role of the Unfolded Protein Response inβCell Compensation and Failure during Diabetes
Abstract
Pancreatic β cell failure leads to diabetes development. During disease progression, β cells adapt their secretory capacity to compensate the elevated glycaemia and the peripheral insulin resistance. This compensatory mechanism involves a fine-tuned regulation to modulate the endoplasmic reticulum (ER) capacity and quality control to prevent unfolded proinsulin accumulation, a major protein synthetized within the β cell. These signalling...
Paper Details
Title
Role of the Unfolded Protein Response inβCell Compensation and Failure during Diabetes
Published Date
Jan 1, 2014
Journal
Volume
2014
Pages
1 - 11
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