Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex
Abstract
Seizures in newborns are associated with a high risk for subsequent epilepsy and adverse neurodevelopmental consequences. Understanding the mechanisms by which neonatal seizures adversely disturb the immature brain is important in developing therapeutic strategies. Using the convulsant agent flurothyl to mimic repetitive neonatal seizures we show that early-life seizures result in long-term alteration in the maintenance phase of long-term...
Paper Details
Title
Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex
Published Date
Sep 1, 2013
Journal
Volume
106
Issue
1-2
Pages
280 - 283
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