Characterization of G protein coupling mediated by the conserved D134^3.49 of DRY motif, M241^6.34, and F251^6.44 residues on human CXCR1

CXCR1, a receptor for interleukin‐8 (IL‐8), plays an important role in defending against pathogen invasion during neutrophil‐mediated innate immune response. Human CXCR1 is a G protein‐coupled receptor (GPCR) with its characteristic seven transmembrane domains (TMs). Functional and structural analyses of several GPCRs have revealed that conserved residues on TM3 (including the highly conserved Asp‐Arg‐Tyr (DRY) motif) and TM6 near intracellular...