The method of repair in epithelial wounds of the cornea

Published on May 1, 1943in Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology2.064
路 DOI :10.1002/AR.1090860106
Leslie B. Arey22
Estimated H-index: 22
(NU: Northwestern University),
W. M. Covode1
Estimated H-index: 1
(NU: Northwestern University)
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Abstract
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#1J. M. Ortiz Pic贸n (LMU: Ludwig Maximilian University of Munich)H-Index: 1
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#1Theodor BoveriH-Index: 17
#2Marcella BoveriH-Index: 1
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#1D. BarfurthH-Index: 1
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#1Paul FraisseH-Index: 1
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Cited By47
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: Vision is essential for amphibians, so a healthy ocular surface is critically important. There are ocular surface abnormalities that occur predominantly in captive animals, such as corneal lipidosis, whereas others, such as UV-induced trauma or infectious and parasitic conditions, may be critical to survival for animals in the wild. It is believed that inherited defects are going to be seen in small captive populations but it may be that confined wild groups of amphibians can be just as severe...
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#1Thomas F. Mauger (OSU: Ohio State University)H-Index: 13
#2Richard M. Hill (OSU: Ohio State University)H-Index: 24
: A micropolarographic system was used as a quantitative means of monitoring the healing course of corneal epithelium following a 10 second exposure to 0.20 N sodium hydroxide solution. Concentrations of less than that strength produced inconsistent flux baselines due to incomplete damage to the epithelium, while higher concentrations commonly involved the stroma as well. Virtually complete epithelial destruction (down to the basement membrane) and reproducible flux baselines were found, however...
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#1Ayad A. FarjoH-Index: 1
#2Mark L. McDermottH-Index: 1
Last. H. Kaz SoongH-Index: 1
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#1H. A. S. van den Brenk (RCS: Royal College of Surgeons of England)H-Index: 2
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#1James D. Zieske (Harvard University)H-Index: 56
#2Claudia M. Francesconi (Harvard University)H-Index: 7
Last. Xiaoqing Guo (Harvard University)H-Index: 13
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The ocular surface provides an outstanding model to examine the regulation of the proliferative cell cycle. Cells within the cornea and conjunctiva exhibit a wide range of proliferative abilities ranging from the rapidly proliferating cells in the basal cell layer of the epithelium to the quiescent keratocytes and endothelial cells. In this review, dedicated to Dr David Maurice, we will discuss four families of proteins known to regulate the cell cycle. These families include: (1) the cyclins; (...
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#1James D. Zieske (Harvard University)H-Index: 56
#2Audrey E. K. Hutcheon (Harvard University)H-Index: 24
Last. Nancy C. Joyce (Harvard University)H-Index: 34
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PURPOSE. It has been demonstrated that cells migrating to cover an epithelial debridement wound exit the cell cycle and that the cell-cycle inhibitor p15 INK4b is upregulated in these cells. TGF-尾 signaling has been implicated in both of these processes, and this study was conducted to determine whether the expression and localization of TGF-尾 receptor (T尾R)-I and -II are altered during corneal epithelial wound repair. METHODS. Three-millimeter superficial keratectomy wounds and 3-mm debridement...
Abstract During corneal epithelial wound repair, cells migrating to cover the wound area exhibit a drastic reduction in proliferative activity. In contrast, cells distal to the original wound exhibit a greatly enhanced level of proliferative activity. At least 90% of the basal cells in limbal and peripheral corneal epithelia synchronously progress through the cell cycle. The question addressed in this article is whether cyclin-dependent kinase inhibitors play a role in the alterations in prolife...
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#1Ian S. Zagon (PSU: Pennsylvania State University)H-Index: 71
#2Joseph W. Sassani (PSU: Pennsylvania State University)H-Index: 27
Last. Patricia J. McLaughlin (PSU: Pennsylvania State University)H-Index: 74
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Abstract To determine the fate of ocular surface epithelial cells in response to corneal injury, epithelial cells undergoing DNA synthesis were labeled at discrete time points following abrasion. A 3-mm diameter epithelial defect was made in the center of the rat cornea. One hour prior to sacrifice, animals received an intraperitoneal injection of [ 3 H ]-thymidine. DNA synthesis in the regenerating epithelium was of low abundance (
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#1Eui鈥揌ong Chung (Harvard University)H-Index: 1
#2Audrey E. K. Hutcheon (Harvard University)H-Index: 24
Last. James D. Zieske (Harvard University)H-Index: 56
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PURPOSE. This study's intention was to examine the progression of ocular surface epithelium through the G1/S transition of the cell cycle after corneal epithelial debridement. METHODS. Three-millimeter debridements were made in central rat cornea and allowed to heal 4 to 48 hours in vivo. Unwounded contralateral eyes served as controls. Two hours before the animals were killed, 5-bromo-2-deoxyuridine (BrdU) was injected to detect S-phase cells. Incorporated BrdU was visualized by indirect immuno...
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