Targeting B Lymphocytes in Progressive Fibrosing Mediastinitis

To the Editor: Fibrosing mediastinitis is an uncommon disorder characterized by inflammation and progressive fibrosis within the mediastinum (1–3). The resulting invasive obstruction of vital mediastinal structures is associated with significant morbidity (2, 4). Infectious and noninfectious inflammatory triggers have been reported (4). In North America, fibrosing mediastinitis is most commonly associated with histoplasmosis (4, 5). Although...