Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats

Gout is characterized by the deposition of monosodium urate (MSU) crystals. Despite being one of the most painful forms of arthritis, gout and the mechanisms responsible for its acute attacks are poorly understood. In the present study, we found that MSU caused dose-related nociception (ED50 [ie, the necessary dose of MSU to elicit 50% of the response relative to the control value] = 0.04 [95% confidence interval 0.01–0.11] mg/paw) and edema...