Study on the structure–function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol

This study was aimed to investigate structure–function relationship of 20(S)-panaxadiol (PD) and its epimeric derivatives ((20S, 24S)-epoxy-dammarane-3β, 12β, 25-triol, PDD1 and (20S, 24R)-epoxy-dammarane-3β, 12β, 25-triol, PDD2) in myocardial ischemia injury in rats. It was shown that PD and PDD2 resulted in a reduction in creatine kinase activity. PD and PDD2 inhibited the elevation of malondialdehyde content, the reduction of superoxide...