Increased Splenic FDG Uptake on PET in Beta-Thalassemia

A 63-year-old woman with a history of anemia resulting from β-thalassemia minor was referred for whole-body positron emission tomography (PET) with F-18-FDG. She had a provisional diagnosis of pulmonary malignancy or lymphoma. PET showed moderate, diffuse F-18 FDG uptake in both lungs in a pattern consistent with inflammation and also splenomegaly with homogeneously increased FDG uptake. Biopsy of the pulmonary lesions revealed a diagnosis of...