iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

Volume: 112, Issue: 19, Pages: 6080 - 6085
Published: May 12, 2015
Abstract
The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam17−/− mice die perinatally with open eyes, like Egfr−/− mice. A hallmark feature of ADAM17-dependent EGFR ligand shedding is that it can be rapidly...
Paper Details
Title
iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
Published Date
May 12, 2015
Volume
112
Issue
19
Pages
6080 - 6085
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