Olmesartan and telmisartan comparably preserve pancreatic beta-cell mass with reduction of oxidative stress in db/db mice

Several clinical studies have provided evidence that blockade of the renin–angiotensin system (RAS) prevents onset of type 2 diabetes. In mice models of type 2 diabetes, some angiotensin II type 1 receptor blockers (ARBs) reportedly protect against reduction of beta-cell mass. Although several ARBs are commercially available, the effect of these drugs on beta-cell mass has not been compared directly. The purpose of this study was to compare the...