Structural Fold and Binding Sites of the Human Na+-Phosphate Cotransporter NaPi-II

Volume: 106, Issue: 6, Pages: 1268 - 1279
Published: Mar 1, 2014
Abstract
Phosphate plays essential biological roles and its plasma level in humans requires tight control to avoid bone loss (insufficiency) or vascular calcification (excess). Intestinal absorption and renal reabsorption of phosphate are mediated by members of the SLC34 family of sodium-coupled transporters (NaPi-IIa,b,c) whose membrane expression is regulated by various hormones, circulating proteins, and phosphate itself. Consequently, NaPi-II...
Paper Details
Title
Structural Fold and Binding Sites of the Human Na+-Phosphate Cotransporter NaPi-II
Published Date
Mar 1, 2014
Volume
106
Issue
6
Pages
1268 - 1279
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