A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.

Pain7.40
Volume: 156, Issue: 5, Pages: 890 - 903
Published: May 1, 2015
Abstract
The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials. This may have occurred because AEA also activates transient receptor potential vanilloid type 1 (TRPV1), which contributes to pain development. Therefore, we investigated the effectiveness of the dual FAAH–TRPV1 blocker OMDM-198 in an MIA-model of...
Paper Details
Title
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Published Date
May 1, 2015
Journal
Volume
156
Issue
5
Pages
890 - 903
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