Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression
Abstract
Baculovirus has emerged as a new gene delivery vector thanks to a number of advantages. This study demonstrated that baculovirus conferred efficient gene delivery and mediated expression of growth factors (TGF-β1, IGF-1 and BMP-2) to therapeutic levels in rabbit chondrocytes. Interestingly, the cellular response to growth factor stimulation was dependent on the cell passage. The highly de-differentiated passage 5 (P5) chondrocytes failed to...
Paper Details
Title
Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression
Published Date
Aug 1, 2007
Journal
Volume
28
Issue
23
Pages
3437 - 3447
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