Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages
Volume: 77, Issue: 3, Pages: 417 - 423
Published: Apr 1, 2011
Abstract
Spherical and rod-shaped gold nanoparticles with surface poly(ethylene glycol) (PEG) chains were characterized for size, shape, charge, poly dispersity and surface plasmon resonance. The nanoparticles were injected intravenously to 6-8-week-old female nu/nu mice bearing orthotopic ovarian tumors, and their biodistribution in vital organs was compared. Gold nanorods were taken up to a lesser extent by the liver, had longer circulation time in the...
Paper Details
Title
Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages
Published Date
Apr 1, 2011
Volume
77
Issue
3
Pages
417 - 423
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