Chemometric Approach in Studying of the Retention Behavior and Lipophilicity of Potentially Biologically ActiveN-Substituted-2-phenylacetamide Derivatives

The potential biological activity of a molecule largely depends on its lipophilicity. The lipophilicity of derivatives of N-substituted-2-phenylacetamide was investigated experimentally, by applying thin-layer chromatography on reversed phase (RP-TLC on RP 18 F254s) in the presence of ethanol and dioxane and by using relevant software packages. In order to establish dependence between lipophilicity obtained in different ways, linear regression...