Emerging roles of ADAM and ADAMTS metalloproteinases in cancer

Published on Feb 1, 2008in Biochimie3.413
· DOI :10.1016/J.BIOCHI.2007.08.008
Natacha Rocks18
Estimated H-index: 18
(University of Liège),
Geneviève Paulissen16
Estimated H-index: 16
(University of Liège)
+ 6 AuthorsDidier Cataldo49
Estimated H-index: 49
(University of Liège)
A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural features distinguish the membrane-anchored ADAMs and the secreted ADAMs with thrombospondin motifs referred to as ADAMTSs. By acting on a large panel of membrane-associated and extracellular substrates, they control several cell functions such as adhesion, fusion, migration and proliferation. The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions.
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