Role of serotonin in the pathophysiology of the irritable bowel syndrome
Abstract
The irritable bowel syndrome (IBS) is a complex disorder that is associated with altered gastrointestinal motility, secretion, and sensation. Serotonin (5-HT) is an important neurotransmitter and paracrine signalling molecule in the gastrointestinal tract. 5-HT release from enterochromaffin (EC) cells initiates peristaltic, secretory, vasodilatory, vagal and nociceptive reflexes. The enteric nervous system (ENS) comprises a semiautonomous...
Paper Details
Title
Role of serotonin in the pathophysiology of the irritable bowel syndrome
Published Date
Apr 1, 2004
Volume
141
Issue
8
Pages
1285 - 1293
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