In vitro anti-inflammatory activities of new steroidal antedrugs: [16α,17α-d] Isoxazoline and [16α,17α-d]-3′-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9α-fluoroprednisolone

A series of new anti-inflammatory steroidal antedrugs with C-16,17-isoxazoline ring system were synthesized and their pharmacological activities were evaluated. We reported earlier that these compounds are promising antedrugs based on the results of 5-day rat croton oil ear edema assay. In the present study, most of these compounds showed high binding affinities to the glucocorticoid receptor of liver cytosol....