Platelet-associated complement factor H in healthy persons and patients with atypical HUS
Abstract
Atypical hemolytic uremic syndrome (aHUS) is associated with complement system dysregulation, and more than 25% of pediatric aHUS cases are linked to mutations in complement factor H (CFH) or CFH autoantibodies. The observation of thrombocytopenia and platelet-rich thrombi in the glomerular microvasculature indicates that platelets are intimately involved in aHUS pathogenesis. It has been reported that a releasable pool of platelet CFH...
Paper Details
Title
Platelet-associated complement factor H in healthy persons and patients with atypical HUS
Published Date
Nov 12, 2009
Journal
Volume
114
Issue
20
Pages
4538 - 4545
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