Inflammation in osteoarthritis

This review focuses on the novel stress-induced and proinflammatory mechanisms underlying the pathogenesis of osteoarthritis, with particular attention to the role of synovitis and the contributions of other joint tissues to cellular events that lead to the onset and progression of the disease and irreversible cartilage damage.Studies during the past 2 years have uncovered novel pathways that, when activated, cause the normally quiescent...