SEX DIFFERENCES IN IMMUNE RESPONSES TO CEPHALOTHIN IN GUINEA PIGS

Published on Feb 13, 1998in Journal of Toxicological Sciences1.737
· DOI :10.2131/JTS.23.87
Tetsuo Aida6
Estimated H-index: 6
,
Nobuhiro Ishikawa3
Estimated H-index: 3
,
Kenkichi Shinkai4
Estimated H-index: 4
Sources
Abstract
Guinea pigs of two strains, outbred Hartley and inbred Strain 2, were immunized sub-cutaneously with cephalothin (CET, 20 mg/body) alone, without adjuvant. Immune responses to the antibiotic were assessed by guinea-pig passive cutaneous anaphylaxis (GP-PCA) and active systemic anaphylaxis (GP-ASA) reactions. The immune response to CET in the female Hartley guinea pigs was higher than that in the males. In contrast, no difference in response to CET in Strain 2 guinea pigs was observed between males and females. These results suggested that female Hartley guinea pigs possessing a higher response should be employed in antigenicity studies involving the β-lactam antibiotics.
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