KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus
Abstract
KLF1 is an erythroid specific transcription factor that binds to regulatory regions of erythroid genes. Binding sites of KLF1 are often found near binding sites of GATA-1 and TAL1. In the β-globin locus, KLF1 is required for forming active chromatin structure, although its role is unclear. To explore the role of KLF1 in transcribing the human γ-globin genes, we stably reduced the expression of KLF1 in erythroid K562 cells, compromising its...
Paper Details
Title
KLF1 stabilizes GATA-1 and TAL1 occupancy in the human β-globin locus
Published Date
Mar 1, 2015
Volume
1849
Issue
3
Pages
282 - 289
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