Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
Abstract
The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) susceptibility alleles associated with inflammatory bowel disease, psoriasis and ankylosing spondylitis. IL-23-driven inflammation has primarily been linked to the actions of T-helper type 17 (TH17) cells. Somewhat overlooked, IL-23 also has inflammatory effects on innate immune...
Paper Details
Title
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
Published Date
Apr 1, 2010
Journal
Volume
464
Issue
7293
Pages
1371 - 1375
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Notes
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