Identification of Lynch syndrome among patients with colorectal cancer

Volume: 308, Issue: 15, Pages: 1555 - 1565
Published: Oct 17, 2012
Abstract
Context Lynch syndrome is the most common form of hereditary colorectal cancer (CRC) and is caused by germline mutations in DNA mismatch repair (MMR) genes. Identification of gene carriers currently relies on germline analysis in patients with MMR-deficient tumors, but criteria to select individuals in whom tumor MMR testing should be performed are unclear. Objective To establish a highly sensitive and efficient strategy for the identification...
Paper Details
Title
Identification of Lynch syndrome among patients with colorectal cancer
Published Date
Oct 17, 2012
Journal
Volume
308
Issue
15
Pages
1555 - 1565
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