Evaluation of Targets for Maytansinoid ADC Therapy Using a Novel Radiochemical Assay
Abstract
Many antibody-drug conjugates (ADCs) become active only after antigen-mediated internalization and release of the cytotoxic agent via antibody degradation. Quantifying these processes can provide critical information on the suitability of a particular receptor target or antibody for ADC therapy by providing insight into the amount of cytotoxic agent released. We describe a simple and inexpensive radiolabel assay to monitor this process in...
Paper Details
Title
Evaluation of Targets for Maytansinoid ADC Therapy Using a Novel Radiochemical Assay
Published Date
Jan 29, 2015
Journal
Volume
32
Issue
11
Pages
3593 - 3603
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