Distribution of DNA Adducts and Corresponding Tissue Damage of Sprague–Dawley Rats with Percutaneous Exposure to Sulfur Mustard
Abstract
Sulfur mustard (SM) is a highly reactive alkylation vesicant and cytotoxic agent that has been recognized as an animal and human carcinogen. Although the exact mechanism of toxicology is vague, DNA alkylation seems to be responsible for the triggering of apoptosis. In this study, after male adult Sprague–Dawley rats were cutaneous exposed to a low concentration of SM at parts-per-million levels, their lungs, livers, pancreases, spleens, marrow,...
Paper Details
Title
Distribution of DNA Adducts and Corresponding Tissue Damage of Sprague–Dawley Rats with Percutaneous Exposure to Sulfur Mustard
Published Date
Feb 16, 2015
Volume
28
Issue
3
Pages
532 - 540
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