Resistance to acetaminophen-induced hepatotoxicity in <i>glutathione S-transferase Mu 1</i>-null mice
Abstract
We investigated the role of glutathione S-transferases Mu 1 (GSTM1) in acetaminophen (APAP)-induced hepatotoxicity using Gstm1-null mice. A single oral administration of APAP resulted in a marked increase in plasma alanine aminotransferase accompanied by hepatocyte necrosis 24 hr after administration in wild-type mice, but its magnitude was unexpectedly attenuated in Gstm1-null mice. Therefore, it is suggested that Gstm1-null mice are resistant...
Paper Details
Title
Resistance to acetaminophen-induced hepatotoxicity in <i>glutathione S-transferase Mu 1</i>-null mice
Published Date
Jan 1, 2012
Volume
37
Issue
3
Pages
595 - 605
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