Development of subtype-selective oestrogen receptor-based therapeutics
Abstract
The two oestrogen receptor subtypes α and β are hormone-regulated modulators of intracellular signalling and gene expression. Regulation of oestrogen receptor activity is crucial not only for development and homeostasis but also for the treatment of various diseases and symptoms. Classical selective oestrogen receptor modulators are well established in the treatment of breast cancer and osteoporosis, but emerging data suggest that the...
Paper Details
Title
Development of subtype-selective oestrogen receptor-based therapeutics
Published Date
Sep 16, 2011
Volume
10
Issue
10
Pages
778 - 792
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