Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors
Abstract
T cells are the most potent cells of the immune system; however, they fail in the immunosurveillance of tumors. In previous decades, scientists began studying methods to take advantage of T-cell potency in cancer therapy by redirecting them against tumors independently from the T-cell receptor-defined specificity. Among different approaches, the most promising are the use of bispecific antibodies and T-cell engineering to create chimeric antigen...
Paper Details
Title
Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors
Published Date
Apr 1, 2013
Journal
Volume
9
Issue
4
Pages
527 - 539
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Notes
History