Cu-catalyzed concise synthesis of pyridines and 2-(1H)-pyridones from acetaldehydes and simple nitrogen donors.

Published on Jan 28, 2015in Organic Letters6.091
· DOI :10.1021/OL5035996
Ziyuan Li11
Estimated H-index: 11
(PKU: Peking University),
Xiaoqiang Huang21
Estimated H-index: 21
+ 3 AuthorsNing Jiao74
Estimated H-index: 74
A highly selective copper-catalyzed concise synthesis of 3,5-diarylpyridine and 2-(1H)-pyridone has been achieved through cascade Chichibabin-type cyclization, C(sp3)–C(sp3) cleavage, and aerobic oxidation. Azide, ceric ammonium nitrate (CAN), and 2-aminopyridine are disclosed as efficient nitrogen donors in this Cu-catalysis using O2 as the oxidant. Water and molecular oxygen were employed as the oxygen source in the case of oxygenation.
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