Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI
Abstract
The two glucose analogs 2-deoxy-D-glucose (2-DG) and 2-fluoro-2-deoxy-D-glucose (FDG) are preferentially taken up by cancer cells, undergo phosphorylation and accumulate in the cells. Owing to their exchangeable protons on their hydroxyl residues they exhibit significant chemical exchange saturation transfer (CEST) effect in MRI. Here we report CEST-MRI on mice bearing orthotopic mammary tumors injected with 2-DG or FDG. The tumor exhibited an...
Paper Details
Title
Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI
Published Date
Oct 25, 2013
Journal
Volume
3
Issue
1
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