Are patients undergoing treatment of hyperlipidaemia with statins the best candidates for early cardiac rehabilitation

Published on Nov 8, 2011in Archives of Medical Science2.807
· DOI :10.5114/AOMS.2011.25548
Rafał Celiński2
Estimated H-index: 2
,
Anna Grzywa-Celińska5
Estimated H-index: 5
+ 2 AuthorsJerzy Mosiewicz12
Estimated H-index: 12
Sources
Abstract
The role of statins in the primary and secondary prevention of cardiovascular events is well known. An important adverse event associated with statin treatment is myopathy; intensive physical effort in patients treated with statins increases the risk of muscle injury/myopathy. In this article we discuss the benefits and risks associated with statin treatment in patients undergoing cardiac rehabilitation after acute coronary syndromes and/or coronary revascularization procedures. In our opinion, the benefits of the secondary prevention of coronary heart disease achieved with statins seem to outweigh the hazards associated with statin therapy. The careful selection of patients for both treatment with statins and the gradual intensification of physical training in the course of cardiac rehabilitation appears to constitute an important element of the therapeutic approach.
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Statin treatment and exercise training can improve lipid profile when administered separately. The efficacy of exercise and statin treatment combined, and its impact on myalgia and serum creatine kinase (CK) have not been completely addressed. The purpose of this study was to determine the effect of statin treatment and the addition of exercise training on lipid profile, including oxidized low-density lipoprotein (oxLDL), and levels of CK and alanine transaminase. Thirty-one hypercholesterolemic...
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