Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-β-cyclodextrin following subcutaneous injection in sheep
Volume: 397, Issue: 1-2, Pages: 96 - 102
Published: Sep 1, 2010
Abstract
Post-injection precipitation may cause poor and erratic drug absorption and tissue irritation at the injection site. Tissue tolerance and pharmacokinetics of a low pH ricobendazole (RBZ) injectable containing 20% hydroxypropyl-β-cyclodextrin (HP-β-CD) were simultaneously investigated after subcutaneous injection in sheep compared to a reference formulation without HP-β-CD. Each animal received a RBZ containing formulation on one side of the back...
Paper Details
Title
Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-β-cyclodextrin following subcutaneous injection in sheep
Published Date
Sep 1, 2010
Volume
397
Issue
1-2
Pages
96 - 102
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