Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats.
Abstract
This study has optimised the poly lactic-co-glycolic acid (PLGA) nano-formulation of curcumin to prolong its retention time in the body and improve bioavailability. High-pressure emulsification-solvent-evaporation was designed to obtain curcumin-loaded PLGA nanoparticles (C-NPs) prepared with 2% of PVA containing 20% sucrose as aqueous phase and dichloromethane as oil phase. The size and entrapment efficiency of C-NPs was 158±10nm and...
Paper Details
Title
Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats.
Published Date
Aug 1, 2011
Journal
Volume
127
Issue
3
Pages
918 - 925
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Notes
History