N -methyl- N -nitrosourea-induced retinal degeneration in mice
Abstract
Mouse retinal degeneration models have been investigated for many years in the hope of understanding the mechanism of photoreceptor cell death. N -methyl- N -nitrosourea (MNU) has been previously shown to induce outer retinal degeneration in mice. After MNU was intraperitoneally injected in C57/BL mice, we observed a gradual decrease in the outer nuclear layer (ONL) thickness associated with photoreceptor outer segment loss, bipolar cell...
Paper Details
Title
N -methyl- N -nitrosourea-induced retinal degeneration in mice
Published Date
Apr 1, 2014
Journal
Volume
121
Pages
102 - 113
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