ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Science56.90
Volume: 314, Issue: 5806, Pages: 1792 - 1795
Published: Dec 15, 2006
Abstract
Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors. Neutrophils rapidly hydrolyze released ATP to adenosine that then acts via A3-type adenosine receptors, which are recruited to the leading...
Paper Details
Title
ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors
Published Date
Dec 15, 2006
Journal
Volume
314
Issue
5806
Pages
1792 - 1795
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