Clinical significance of diffusely increased splenic uptake on FDG-PET

Diffusely increased uptake is more commonly observed than focal uptake in the spleen on a whole-body [18F] fluorodeoxyglucose-positron emission tomography/computed tomography. The significance of diffusely increased splenic uptake varies in different clinical settings. On a pre-therapeutic scan for lymphoma, splenic uptake, greater than hepatic uptake, is a relative reliable indication of lymphomatous involvement of the spleen, unless the...